{"id":406906,"date":"2026-08-02T16:08:11","date_gmt":"2026-08-02T16:08:11","guid":{"rendered":"https:\/\/wordpress-1321984-6663721.cloudwaysapps.com\/pipeline\/denfivontinib\/"},"modified":"2026-09-24T10:40:40","modified_gmt":"2026-09-24T10:40:40","slug":"denfivontinib","status":"publish","type":"page","link":"https:\/\/oscotec.com\/ko\/science\/pipeline\/denfivontinib\/","title":{"rendered":"Denfivontinib"},"content":{"rendered":"
\n
\n
\n

Denfivontinib<\/h2><\/div><\/div>\n\n

Denfivontinib\uc740 FLT3<\/strong> \ubc0f AXL<\/strong> \ud0a4\ub098\uc544\uc81c\ub97c \uc120\ud0dd\uc801\uc73c\ub85c \ub3d9\uc2dc\uc5d0 \ud45c\uc801\ud558\ub294 \uc800\ubd84\uc790 \uc774\uc911 \uc5b5\uc81c\uc81c\ub85c, \ud608\uc561\uc554\uacfc \uace0\ud615\uc554 \ubaa8\ub450\uc5d0 \uc801\uc6a9 \uac00\ub2a5\ud55c \ucc28\ubcc4\ud654\ub41c \uce58\ub8cc \uc804\ub7b5\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n\n

\n\n\n
\n <\/span>\n \ud30c\ud2b8\ub108\uc0ac \u00b7 YATIRI BIO<\/span>\n <\/div>\n\n<\/div>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\uac1c\ubc1c \ub2e8\uacc4<\/h6>\n<\/div><\/div>\n\n

\uc784\uc0c1 1\uc0c1<\/strong> \u2014 \uc7ac\ubc1c\uc131\/\ubd88\uc751\uc131 AML \ubc0f \uc9c4\ud589\uc131 \uace0\ud615\uc554 \ub300\uc0c1 \uc784\uc0c1\uc2dc\ud5d8 \uc644\ub8cc<\/h3>\n<\/div><\/div>\n\n
\n\n \n
\n
<\/div>\n <\/div>\n\n \n
\n\n
\n \ud6c4\ubcf4\ubb3c\uc9c8 \ubc1c\uad74\n <\/div>\n\n
\n \ube44\uc784\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 1\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 2\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 3\uc0c1\n <\/div>\n\n
\n \uc2b9\uc778 \/
\n \uc0c1\uc6a9\ud654\n <\/div>\n\n <\/div>\n\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\ud575\uc2ec \uc815\ubcf4<\/h6>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\ud45c\uc801<\/h6>\n

FLT3 \/ AXL<\/h4>\n<\/div><\/div>\n\n

\uc885\uc591\uc138\ud3ec\uc758 \uc0dd\uc874, \uc99d\uc2dd \ubc0f \uce58\ub8cc \uc800\ud56d\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \uc218\uc6a9\uccb4 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
\uc801\uc751\uc99d<\/h6>\n

AML \/ \uace0\ud615\uc554<\/h4>\n<\/div><\/div>\n\n

\uc608\uce21 \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \uc804\ub7b5\uc744 \ud1b5\ud574 \uc120\ubcc4\ub41c AML \ud658\uc790 \ubc0f \uc9c4\ud589\uc131 \uace0\ud615\uc554 \ud658\uc790<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
\ubaa8\ub2ec\ub9ac\ud2f0<\/h6>\n

\uc800\ubd84\uc790 \ud654\ud569\ubb3c<\/h4>\n<\/div><\/div>\n\n

\uacbd\uad6c\uc6a9 FLT3\/AXL \uc774\uc911 \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>\ubbf8\ucda9\uc871 \uc758\ub8cc \uc218\uc694 \ubc0f \uac1c\ubc1c \uadfc\uac70
\n<\/span><\/div>\n<\/div><\/div>\n\n

AML\uc758 \ub0b4\uc131\uacfc \uc774\uc9c8\uc131\uc740 FLT3\/AXL \uc774\uc911 \uc5b5\uc81c \ubc0f \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \ud658\uc790 \uc120\ubcc4 \uc804\ub7b5\uc758 \uadfc\uac70\uac00 \ub429\ub2c8\ub2e4.<\/h2>\n

\uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1(AML)\uc740 \uce58\ub8cc \uc800\ud56d\uc131\uacfc \uc7ac\ubc1c\ub960\uc774 \ub192\uc740 \uacf5\uaca9\uc801\uc774\uba70 \ubd84\uc790\uc801\uc73c\ub85c \uc774\uc9c8\uc801\uc778 \uc545\uc131\uc885\uc591\uc785\ub2c8\ub2e4. FLT3 \ud45c\uc801 \uce58\ub8cc\ub294 FLT3 \ubcc0\uc774 AML\uc758 \uce58\ub8cc \uc131\uacfc\ub97c \uac1c\uc120\ud588\uc9c0\ub9cc, \uc774\ucc28 FLT3 \ubcc0\uc774, \ubcf4\uc0c1\uc131 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c \ubc0f \ud074\ub860 \uc9c4\ud654 \ub4f1\uc744 \ud1b5\ud574 \ub0b4\uc131\uc774 \ube48\ubc88\ud558\uac8c \ubc1c\uc0dd\ud569\ub2c8\ub2e4. AXL \uc2e0\ud638\uc804\ub2ec\uc740 \ucd94\uac00\uc801\uc778 \uc0dd\uc874 \ubc0f \ub0b4\uc131 \uacbd\ub85c\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uc73c\uba70, AML\uacfc \uc5ec\ub7ec \uace0\ud615\uc554\uc5d0\uc11c \uc885\uc591 \uc9c4\ud589 \ubc0f \uce58\ub8cc \uc800\ud56d\uc131\uacfc\uc758 \uc5f0\uad00\uc131\uc774 \ubcf4\uace0\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.
FLT3\uc640 AXL\uc758 \uc774\ub7ec\ud55c \uc0c1\ud638\ubcf4\uc644\uc801 \uc5ed\ud560\uc740 \uc885\uc591\uc720\ubc1c \uc2e0\ud638\uc640 \uc801\uc751\uc131 \ub0b4\uc131\uc744 \ub3d9\uc2dc\uc5d0 \uc5b5\uc81c\ud558\ub294 \uc774\uc911 \ud45c\uc801 \uc804\ub7b5\uc758 \uadfc\uac70\uac00 \ub429\ub2c8\ub2e4. \ub610\ud55c AML\uc758 \uce58\ub8cc \uac10\uc218\uc131\uc740 \ub2e8\uc77c \ubcc0\uc774\ub9cc\uc73c\ub85c \ucda9\ubd84\ud788 \uaddc\uc815\ub418\uc9c0 \uc54a\uc744 \uc218 \uc788\uc73c\ubbc0\ub85c, \uce58\ub8cc \ud61c\ud0dd \uac00\ub2a5\uc131\uc774 \ub192\uc740 \ud658\uc790\ub97c \uc120\ubcc4\ud558\uae30 \uc704\ud55c \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \ud658\uc790 \uc120\ubcc4 \uc804\ub7b5\uc774 \uc911\uc694\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>\uc791\uc6a9 \uae30\uc804 \ubc0f \uc8fc\uc694 \ud2b9\uc9d5
\n<\/span><\/div>\n<\/div><\/div>\n\n

\uc885\uc591\uc720\ubc1c \uc2e0\ud638\uc640 \uce58\ub8cc \uc800\ud56d\uc131\uc744 \ud45c\uc801\ud558\ub294 FLT3\/AXL \uc774\uc911 \uc5b5\uc81c<\/h3>\n<\/div><\/div>\n\n

Denfivontinib\uc740 \uc885\uc591\uc138\ud3ec\uc758 \uc0dd\uc874, \uc99d\uc2dd \ubc0f \uce58\ub8cc \uc800\ud56d\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \ub450 \uc218\uc6a9\uccb4 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c\uc778 FLT3\uc640 AXL\uc744 \ub3d9\uc2dc\uc5d0 \ud45c\uc801\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uacbd\uad6c\uc6a9 \uc800\ubd84\uc790 \ud0a4\ub098\uc544\uc81c \uc5b5\uc81c\uc81c\uc785\ub2c8\ub2e4. AML\uc5d0\uc11c FLT3 \ud65c\uc131\ud654 \ubcc0\uc774\ub294 \ubc31\ud608\ubcd1 \uc138\ud3ec\uc758 \uc99d\uc2dd\uacfc \uc0dd\uc874\uc744 \ucd09\uc9c4\ud558\ub294 \uc885\uc591\uc720\ubc1c \uc2e0\ud638\ub97c \ud65c\uc131\ud654\ud558\uba70, AXL\uc740 \ud654\ud559\uc694\ubc95, \ud45c\uc801\uce58\ub8cc\uc81c \ubc0f \uba74\uc5ed \uae30\ubc18 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc800\ud56d\uc131\uacfc \uad00\ub828\ub41c \ucd94\uac00\uc801\uc778 \uc0dd\uc874 \ubc0f \ud68c\ud53c \uacbd\ub85c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. Denfivontinib\uc740 FLT3\uc640 AXL\uc744 \ub3d9\uc2dc\uc5d0 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \uc7ac\ubc1c\uacfc \uc9c8\ud658 \uc9c0\uc18d\uc131\uc5d0 \uae30\uc5ec\ud558\ub294 \uc885\uc591\uc720\ubc1c \ub4dc\ub77c\uc774\ubc84 \uc2e0\ud638\uc640 \ubcf4\uc0c1\uc131 \ub0b4\uc131 \uacbd\ub85c\ub97c \ud568\uaed8 \uc5b5\uc81c\ud558\ub3c4\ub85d \uc124\uacc4\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ube44\uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c Denfivontinib\uc740 \uae30\uc874 FLT3 \uc5b5\uc81c\uc81c \uce58\ub8cc \ud6c4 \uc7ac\ubc1c\uacfc \uad00\ub828\ub41c FLT3 \ubcc0\uc774\uccb4\uc5d0 \ub300\ud574 \uac15\ub825\ud55c \ud65c\uc131\uc744 \ubcf4\uc600\uc73c\uba70, AML \ud658\uc790 \uc720\ub798 \uac80\uccb4\uc5d0\uc11c \ud56d\ubc31\ud608\ubcd1 \ud65c\uc131\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc5ec\ub7ec \uace0\ud615\uc554 \ubaa8\ub378\uc5d0\uc11c AXL \uc2e0\ud638\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uace0 \uba74\uc5ed \uc758\uc874\uc801 \ud56d\uc885\uc591 \ud6a8\uacfc\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. Yatiri Bio\uc640\uc758 \ud611\ub825\uc744 \ud1b5\ud574 FLT3 \ubcc0\uc774 \uc0c1\ud0dc\ub97c \ub118\uc5b4 Denfivontinib \uac10\uc218\uc131\uacfc \uc5f0\uad00\ub41c \ud6c4\ubcf4 \ubc14\uc774\uc624\ub9c8\ucee4 \ud504\ub85c\ud30c\uc77c\uc744 \ucd94\uac00\ub85c \ud3c9\uac00\u00b7\uac80\uc99d\ud558\uace0 \uc788\uc73c\uba70, \ud5a5\ud6c4 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ubc14\uc774\uc624\ub9c8\ucee4 \uae30\ubc18 \ud658\uc790 \uc120\ubcc4\uc744 \uc9c0\uc6d0\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
<\/span>\uadfc\uac70 \uc790\ub8cc
\n<\/span><\/div>\n<\/div><\/div>\n\n

\uc8fc\uc694 \ub17c\ubb38 \ubc0f \ud559\uc220 \ubc1c\ud45c<\/h2>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\n
<\/span>
\n\ube44\uc784\uc0c1<\/div>\n
2021\/12<\/div>\n<\/div>\n

SKI\u2010G\u2010801, an AXL kinase inhibitor, blocks metastasis through inducing anti\u2010tumor immune responses and potentiates anti\u2010PD\u20101 therapy in mouse cancer models
\n<\/h4>\n

[Clin Transl Immunology. 2021 Dec 29;11(1):e1364.]\n<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>
\n\ube44\uc784\uc0c1\n<\/div>\n
2014\/02<\/p>\n<\/div>\n<\/div>\n

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia <\/h4>\n

[Blood \u00b7 2014;123(14):2209\u20132219 \u00b7 Hee Kyu Lee, et al.]<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>\ud30c\ud2b8\ub108
\n<\/span><\/div>\n<\/div><\/div>\n\n

YATIRI BIO\uc640 \uc635\uc158 \uacc4\uc57d
\n<\/h2>\n<\/div><\/div>\n\n

\uae00\ub85c\ubc8c \ub3c5\uc810 \ub77c\uc774\uc120\uc2a4 \uc635\uc158 \u00b7 2026\ub144 3\uc6d4<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
<\/span><\/div>\n<\/div>\n<\/div>\n\n
\n
\n

\uc57d\uc5b4 \u2014 AML: \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1 \u00b7 FLT3: FMS \uc720\uc0ac \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c 3 \u00b7 ITD: \ub0b4\ubd80 \uc9c1\ub82c \uc911\ubcf5 \u00b7 TKD: \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c \ub3c4\uba54\uc778 \u00b7 AXL: AXL \uc218\uc6a9\uccb4 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":406869,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"class_list":["post-406906","page","type-page","status-publish","hentry"],"acf":[],"dsm_author":{"name":"Photong","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/8f28831a4c55dba0b38a30b7d6e067203b6e781f27c8cc78bc3ca7d9a9e16ab8?s=96&d=mm&r=g","archive_link":"https:\/\/oscotec.com\/ko\/author\/photong\/","biodata":""},"dsm_categories":[],"dsm_attachment_categories":[],"dsm_featured_image":null,"dsm_comment_count":0,"_links":{"self":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/comments?post=406906"}],"version-history":[{"count":54,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406906\/revisions"}],"predecessor-version":[{"id":410346,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406906\/revisions\/410346"}],"up":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406869"}],"wp:attachment":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/media?parent=406906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}