{"id":406909,"date":"2026-08-02T16:04:50","date_gmt":"2026-08-02T16:04:50","guid":{"rendered":"https:\/\/wordpress-1321984-6663721.cloudwaysapps.com\/pipeline\/cevidoplenib\/"},"modified":"2026-09-24T10:42:24","modified_gmt":"2026-09-24T10:42:24","slug":"cevidoplenib","status":"publish","type":"page","link":"https:\/\/oscotec.com\/ko\/science\/pipeline\/cevidoplenib\/","title":{"rendered":"Cevidoplenib"},"content":{"rendered":"
\n
\n
\n

Cevidoplenib<\/h2><\/div><\/div>\n\n

Cevidoplenib(SKI-O-703)\uc740 \uacbd\uad6c\uc6a9 \uace0\uc120\ud0dd\uc801 SYK(spleen tyrosine kinase) \uc5b5\uc81c\uc81c\ub85c, \ub300\uc2dd\uc138\ud3ec\uc5d0\uc11c SYK \uc758\uc874\uc131 Fc\u03b3 \uc218\uc6a9\uccb4 \uc2e0\ud638\uc804\ub2ec\uc744 \uc5b5\uc81c\ud558\uc5ec \uba74\uc5ed\uc131 \ud608\uc18c\ud310\uac10\uc18c\uc99d(ITP)\uc5d0\uc11c \uc790\uac00\ud56d\uccb4 \ub9e4\uac1c \ud608\uc18c\ud310 \ud30c\uad34\ub97c \uac10\uc18c\uc2dc\ud0a4\ub3c4\ub85d \uc124\uacc4\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n\n

\n\n\n
\n <\/span>\n \uae30\uc220\uc774\uc804 \u00b7 AGIOS\n\n<\/span>\n <\/div>\n\n<\/div>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\uac1c\ubc1c \ub2e8\uacc4<\/h6>\n<\/div><\/div>\n\n

\uc784\uc0c1 2\uc0c1<\/strong> \u2014 \uc9c0\uc18d\uc131 \ub610\ub294 \ub9cc\uc131 ITP \uc131\uc778 \ud658\uc790 \ub300\uc0c1 \uc784\uc0c1\uc2dc\ud5d8 \uc644\ub8cc<\/h3>\n<\/div><\/div>\n\n
\n\n \n
\n
<\/div>\n <\/div>\n\n \n
\n\n
\n \ud6c4\ubcf4\ubb3c\uc9c8 \ubc1c\uad74\n <\/div>\n\n
\n \ube44\uc784\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 1\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 2\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 3\uc0c1\n <\/div>\n\n
\n \uc2b9\uc778 \/
\n \uc0c1\uc6a9\ud654\n <\/div>\n\n <\/div>\n\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\ud575\uc2ec \uc815\ubcf4<\/h6>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\ud45c\uc801<\/h6>\n

SYK<\/h4>\n<\/div><\/div>\n\n

\uba74\uc5ed\uc138\ud3ec \uc2e0\ud638\uc804\ub2ec\uc5d0 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\ub294 \uc138\ud3ec\uc9c8 \ube44\uc218\uc6a9\uccb4\ud615 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
\uc801\uc751\uc99d<\/h6>\n

ITP<\/h4>\n<\/div><\/div>\n\n

\uc9c0\uc18d\uc131 \ub610\ub294 \ub9cc\uc131 \uc6d0\ubc1c\uc131 ITP<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
\ubaa8\ub2ec\ub9ac\ud2f0<\/h6>\n

\uc800\ubd84\uc790 \ud654\ud569\ubb3c<\/h4>\n<\/div><\/div>\n\n

\uacbd\uad6c\uc6a9 \uace0\uc120\ud0dd\uc801 \uc5b5\uc81c\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>\ubbf8\ucda9\uc871 \uc758\ub8cc \uc218\uc694 \ubc0f \uac1c\ubc1c \uadfc\uac70
\n<\/span><\/div>\n<\/div><\/div>\n\n

ITP \ubc0f \uae30\ud0c0 \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc758 \uae30\uc874 \uce58\ub8cc \ud55c\uacc4\ub294 \ubcf4\ub2e4 \uc120\ud0dd\uc801\uc778 SYK \uc5b5\uc81c\uc81c \uac1c\ubc1c\uc758 \uadfc\uac70\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/h2>\n<\/div><\/div>\n\n

\uba74\uc5ed\uc131 \ud608\uc18c\ud310\uac10\uc18c\uc99d(ITP)\uc740 \uc790\uac00\uba74\uc5ed\uc131 \ucd9c\ud608 \uc9c8\ud658\uc73c\ub85c, \ucf54\ub974\ud2f0\ucf54\uc2a4\ud14c\ub85c\uc774\ub4dc, \uc815\ub9e5\uc8fc\uc0ac\uc6a9 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0(IVIG), \ud2b8\ub86c\ubcf4\ud3ec\uc774\uc5d0\ud2f4 \uc218\uc6a9\uccb4 \uc791\uc6a9\uc81c(TPO-RA), \ub9ac\ud22d\uc2dc\ub9d9 \ubc0f \ube44\uc7a5\uc808\uc81c\uc220 \ub4f1\uc758 \uce58\ub8cc\ub97c \ud1b5\ud574 \ud608\uc18c\ud310 \uc218\uce58\ub97c \uac1c\uc120\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uce58\ub8cc \ubc18\uc751\uc758 \uac1c\uc778\ucc28\uc640 \uc9c0\uc18d\uc131 \ubd80\uc871, \uc7ac\ubc1c, \uce58\ub8cc \uad00\ub828 \ub3c5\uc131 \ubc0f \uc7a5\uae30\uac04 \uce58\ub8cc\uc758 \ud544\uc694\uc131 \ub4f1\uc73c\ub85c \uc778\ud574 \uae30\uc874 \uce58\ub8cc\uc5d0\ub294 \ud55c\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud55c\uacc4\ub294 \uc7a5\uae30 \ub0b4\uc57d\uc131\uc744 \uac1c\uc120\ud558\uba74\uc11c \uc9c0\uc18d\uc801\uc778 \uc9c8\ubcd1 \uc870\uc808\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\ub294 \uae30\uc804 \uae30\ubc18 \uce58\ub8cc\uc81c\uc5d0 \ub300\ud55c \ud544\uc694\uc131\uc744 \ub192\uc600\uc2b5\ub2c8\ub2e4.
\nSYK\ub294 Fc\u03b3 \uc218\uc6a9\uccb4 \ubc0f B\uc138\ud3ec \uc218\uc6a9\uccb4(BCR) \ud558\uc704 \uc2e0\ud638\uc804\ub2ec\uc5d0 \uad00\uc5ec\ud558\ub294 \ud575\uc2ec \ud0a4\ub098\uc544\uc81c\ub85c, \uc790\uac00\ud56d\uccb4 \ub9e4\uac1c \ud608\uc18c\ud310 \uc81c\uac70\ubfd0 \uc544\ub2c8\ub77c \uad11\ubc94\uc704\ud55c \uba74\uc5ed\uc138\ud3ec \ud65c\uc131\ud654\uc5d0\ub3c4 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc740 ITP\ubfd0\ub9cc \uc544\ub2c8\ub77c \ube44\uc815\uc0c1\uc801\uc778 Fc \uc218\uc6a9\uccb4 \ub610\ub294 B\uc138\ud3ec \uc218\uc6a9\uccb4 \uc2e0\ud638\uc804\ub2ec\uc5d0 \uc758\ud574 \uc720\ubc1c\ub418\ub294 \ub2e4\ub978 \uc790\uac00\uba74\uc5ed \ubc0f \ud608\uc561\uc9c8\ud658\uc5d0\uc11c\ub3c4 SYK\ub97c \uce58\ub8cc \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uac15\ub825\ud55c \uadfc\uac70\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. 1\uc138\ub300 SYK \uc5b5\uc81c\uc81c\ub97c \ud1b5\ud574 \ud574\ub2f9 \ud45c\uc801\uc758 \uc784\uc0c1\uc801 \uc720\ud6a8\uc131\uc774 \ud655\uc778\ub418\uc5c8\uc73c\ub098, \ubcf4\ub2e4 \uad11\ubc94\uc704\ud55c \ud0a4\ub098\uc544\uc81c \ud65c\uc131\uacfc \ub0b4\uc57d\uc131\uc758 \ud55c\uacc4\ub85c \uc778\ud574 \uc120\ud0dd\uc131\uc774 \ud5a5\uc0c1\ub41c \ucc28\uc138\ub300 SYK \uc5b5\uc81c\uc81c \uac1c\ubc1c\uc758 \ud544\uc694\uc131\uc774 \uc81c\uae30\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

\n
\n
\n
<\/span>\uc791\uc6a9 \uae30\uc804 \ubc0f \uc8fc\uc694 \ud2b9\uc9d5
<\/span><\/div>\n<\/div><\/div>\n\n

\uc790\uac00\ud56d\uccb4 \ub9e4\uac1c \ud608\uc18c\ud310 \ud30c\uad34\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \uc120\ud0dd\uc801 SYK \uc5b5\uc81c<\/h3>\n<\/div><\/div>\n\n

Cevidoplenib\uc740 ITP\uc5d0\uc11c \uc790\uac00\ud56d\uccb4 \ub9e4\uac1c \ud608\uc18c\ud310 \ud30c\uad34\ub97c \uac10\uc18c\uc2dc\ud0a4\ub3c4\ub85d \uc124\uacc4\ub41c \uacbd\uad6c\uc6a9 \uace0\uc120\ud0dd\uc801 SYK \uc5b5\uc81c\uc81c\uc785\ub2c8\ub2e4. \uc790\uac00\ud56d\uccb4\uac00 \uacb0\ud569\ub41c \ud608\uc18c\ud310\uc740 \ub300\uc2dd\uc138\ud3ec\uc758 Fc\u03b3 \uc218\uc6a9\uccb4\uc640 \uacb0\ud569\ud558\uc5ec SYK \uc758\uc874\uc131 \uc2e0\ud638\uc804\ub2ec\uc744 \ud65c\uc131\ud654\ud558\uace0, \uc774\ub97c \ud1b5\ud574 \ud608\uc18c\ud310\uc758 \ud3ec\uc2dd \ubc0f \uc81c\uac70\uac00 \ucd09\uc9c4\ub429\ub2c8\ub2e4. Cevidoplenib\uc740 SYK\ub97c \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \ud608\uc18c\ud310 \ud30c\uad34\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \ud608\uc18c\ud310 \uc218\uce58 \ud68c\ubcf5\uc744 \ub3d5\ub3c4\ub85d \uc124\uacc4\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uae00\ub85c\ubc8c \uc784\uc0c1 2\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c Cevidoplenib\uc740 \uc6a9\ub7c9 \uc758\uc874\uc801\uc778 \ud608\uc18c\ud310 \ubc18\uc751\uc744 \ubcf4\uc600\uc73c\uba70 \uc804\ubc18\uc801\uc73c\ub85c \uc591\ud638\ud55c \ub0b4\uc57d\uc131\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. 1\ucc28 \ud3c9\uac00\ubcc0\uc218\uc5d0\uc11c\ub294 \ud1b5\uacc4\uc801 \uc720\uc758\uc131\uc5d0 \ub3c4\ub2ec\ud558\uc9c0 \ubabb\ud588\uc73c\ub098, \uc5ec\ub7ec 2\ucc28 \ud3c9\uac00\ubcc0\uc218\uc5d0\uc11c \uc784\uc0c1\uc801\uc73c\ub85c \uc758\ubbf8 \uc788\ub294 \ud608\uc18c\ud310 \ubc18\uc751\uc774 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c Cevidoplenib\uc740 2024\ub144 \uc6d0\ubc1c\uc131 ITP\uc5d0 \ub300\ud574 \ubbf8\uad6d FDA \ud76c\uadc0\uc758\uc57d\ud488 \uc9c0\uc815\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
<\/span>\uadfc\uac70 \uc790\ub8cc
\n<\/span><\/div>\n<\/div><\/div>\n\n

\uc8fc\uc694 \ub17c\ubb38 \ubc0f \ud559\uc220 \ubc1c\ud45c<\/h2>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
\n
<\/span>
\n\uc784\uc0c1<\/div>\n
2023\/03<\/div>\n<\/div>\n

A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models
\n<\/h4>\n

Cho S et al. \u00b7 Clin Exp Immunol \u00b7 2023<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n

<\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\n
<\/span>\ud30c\ud2b8\ub108
\n<\/span><\/div>\n<\/div><\/div>\n\n

Agios\uc5d0 \uae30\uc220\uc774\uc804<\/h2>\n<\/div><\/div>\n\n

\ub3c5\uc810\uc801 \uae00\ub85c\ubc8c \ub77c\uc774\uc120\uc2a4 \u00b7 2026\ub144 6\uc6d4
\uc624\uc2a4\ucf54\ud14d\uc740 \uc784\uc0c1 3\uc0c1 \uacb0\uacfc\uc5d0 \ub530\ub77c \ub300\ud55c\ubbfc\uad6d \ub0b4 \ub3c5\uc810 \uac1c\ubc1c \ubc0f \uc0c1\uc6a9\ud654 \uad8c\ub9ac\ub97c \ud655\ubcf4\ud560 \uc218 \uc788\ub294 \uc635\uc158\uc744 \ubcf4\uc720\ud569\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n\n

\n
<\/span><\/div>\n<\/div>\n<\/div>\n\n
\n
\n
\uc57d\uc5b4 \u2014 ITP: \uba74\uc5ed\uc131 \ud608\uc18c\ud310\uac10\uc18c\uc99d \u00b7 SYK: \ube44\uc7a5 \ud2f0\ub85c\uc2e0 \ud0a4\ub098\uc544\uc81c \u00b7 Fc\u03b3R: Fc\u03b3 \uc218\uc6a9\uccb4 \u00b7 BCR: B\uc138\ud3ec \uc218\uc6a9\uccb4 \u00b7 IVIG: \uc815\ub9e5\uc8fc\uc0ac\uc6a9 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0 \u00b7 TPO-RA: \ud2b8\ub86c\ubcf4\ud3ec\uc774\uc5d0\ud2f4 \uc218\uc6a9\uccb4 \uc791\uc6a9\uc81c<\/h6>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":406869,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"class_list":["post-406909","page","type-page","status-publish","hentry"],"acf":[],"dsm_author":{"name":"Photong","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/8f28831a4c55dba0b38a30b7d6e067203b6e781f27c8cc78bc3ca7d9a9e16ab8?s=96&d=mm&r=g","archive_link":"https:\/\/oscotec.com\/ko\/author\/photong\/","biodata":""},"dsm_categories":[],"dsm_attachment_categories":[],"dsm_featured_image":null,"dsm_comment_count":0,"_links":{"self":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406909","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/comments?post=406909"}],"version-history":[{"count":126,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406909\/revisions"}],"predecessor-version":[{"id":410347,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406909\/revisions\/410347"}],"up":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406869"}],"wp:attachment":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/media?parent=406909"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}