{"id":406919,"date":"2026-08-02T16:12:05","date_gmt":"2026-08-02T16:12:05","guid":{"rendered":"https:\/\/wordpress-1321984-6663721.cloudwaysapps.com\/pipeline\/oct-648\/"},"modified":"2026-09-24T10:04:31","modified_gmt":"2026-09-24T10:04:31","slug":"oct-648","status":"publish","type":"page","link":"https:\/\/oscotec.com\/ko\/science\/pipeline\/oct-648\/","title":{"rendered":"OCT-648"},"content":{"rendered":"
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OCT-648<\/h2><\/div><\/div>\n\n

OCT-648\uc740 \uc12c\uc720\ud654 \uad00\ub828 YAP\/TAZ \uc2e0\ud638\uc804\ub2ec\uc744 \uc870\uc808\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uc120\ud0dd\uc801 NUAK1(NUAK family kinase 1) \uc5b5\uc81c\uc81c \ud504\ub85c\uadf8\ub7a8\uc73c\ub85c, \uc9c4\ud589\uc131 \ub9cc\uc131 \uc2e0\uc7a5\uc9c8\ud658(CKD) \ubc0f \uae09\uc131 \uc2e0\uc190\uc0c1(AKI)\uc5d0\uc11c CKD\ub85c\uc758 \uc804\ud658\uc744 \uc8fc\uc694 \uac1c\ubc1c \uc601\uc5ed\uc73c\ub85c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n\n

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\n <\/span>\n \ud30c\ud2b8\ub108\ub9c1 \uac00\ub2a5\n\n <\/div>\n\n\n\n<\/div>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
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\uac1c\ubc1c \ub2e8\uacc4<\/h6>\n<\/div><\/div>\n\n

\ube44\uc784\uc0c1<\/strong> \u2014 IND \uc2e0\uccad\uc744 \uc704\ud55c \uc900\ube44 \ub2e8\uacc4<\/h3>\n<\/div><\/div>\n\n
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<\/div>\n <\/div>\n\n \n
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\n \ud6c4\ubcf4\ubb3c\uc9c8 \ubc1c\uad74\n <\/div>\n\n
\n \ube44\uc784\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 1\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 2\uc0c1\n <\/div>\n\n
\n \uc784\uc0c1 3\uc0c1\n <\/div>\n\n
\n \uc2b9\uc778 \/
\n \uc0c1\uc6a9\ud654\n <\/div>\n\n <\/div>\n\n<\/div><\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n
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\ud575\uc2ec \uc815\ubcf4<\/h6>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n
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\ud45c\uc801<\/h6>\n

NUAK1 <\/h4>\n<\/div><\/div>\n\n

\uc12c\uc720\ud654 \uad00\ub828 YAP\/TAZ \uc2e0\ud638\uc804\ub2ec \ubc0f \uc12c\uc720\uc544\uc138\ud3ec \ud65c\uc131\ud654\uc5d0 \uad00\uc5ec\ud558\ub294 \ud0a4\ub098\uc544\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n\n

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\uc801\uc751\uc99d<\/h6>\n

\uc12c\uc720\ud654<\/h4>\n<\/div><\/div>\n\n

\uc9c4\ud589\uc131 CKD \ubc0f AKI\uc5d0\uc11c CKD\ub85c\uc758 \uc804\ud658<\/p>\n<\/div><\/div>\n<\/div>\n\n

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\ubaa8\ub2ec\ub9ac\ud2f0<\/h6>\n

\uc800\ubd84\uc790 \ud654\ud569\ubb3c<\/h4>\n<\/div><\/div>\n\n

\uacbd\uad6c \ud22c\uc5ec \uac00\ub2a5\ud55c \uc120\ud0dd\uc801 \uc5b5\uc81c\uc81c<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

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<\/span>\ubbf8\ucda9\uc871 \uc758\ub8cc \uc218\uc694 \ubc0f \uac1c\ubc1c \uadfc\uac70\n<\/div>\n<\/div><\/div>\n\n

\uc12c\uc720\ud654\uc5d0 \uc758\ud574 \uc720\ubc1c\ub418\ub294 \uc9c8\ubcd1 \uc9c4\ud589\uc740 \uc5ec\uc804\ud788 \uc911\uc694\ud55c \uce58\ub8cc \ubbf8\ucda9\uc871 \uc601\uc5ed\uc785\ub2c8\ub2e4<\/h2>\n<\/div><\/div>\n\n

\uc12c\uc720\ud654\ub294 \ub2e4\uc591\ud55c \ub9cc\uc131\uc9c8\ud658\uc5d0\uc11c \uc9c4\ud589\uc131 \uc7a5\uae30 \uae30\ub2a5\uc7a5\uc560\uc758 \uae30\uc800\uc5d0 \uc874\uc7ac\ud558\ub294 \uacf5\ud1b5\uc801\uc778 \ubcd1\ub9ac \uacfc\uc815\uc785\ub2c8\ub2e4. \uc2e0\uc7a5\uc5d0\uc11c\ub294 \ub2e4\uc591\ud55c \uc6d0\uc778\uc758 \ub9cc\uc131 \uc2e0\uc7a5\uc9c8\ud658(CKD)\uc5d0\uc11c \uae30\ub2a5\uc774 \uc810\uc9c4\uc801\uc73c\ub85c \uc800\ud558\ub418\ub294 \ud575\uc2ec \uae30\uc804\uc73c\ub85c \uc791\uc6a9\ud569\ub2c8\ub2e4. \ud604\uc7ac \uce58\ub8cc\ub294 RAS \uc5b5\uc81c\uc81c \ubc0f SGLT2 \uc5b5\uc81c\uc81c\ub97c \ud3ec\ud568\ud55c \ud45c\uc900 \uce58\ub8cc\ub97c \uc911\uc2ec\uc73c\ub85c \ud558\uba70, \ud544\uc694\ud55c \uacbd\uc6b0 \ud608\uc555 \ubc0f \ud608\ub2f9 \uc870\uc808\uc744 \ubcd1\ud589\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc12c\uc720\ud654 \uacfc\uc815 \uc790\uccb4\ub97c \uc9c1\uc811 \ud45c\uc801\ud558\ub294 \uce58\ub8cc \uc635\uc158\uc740 \uc5ec\uc804\ud788 \uc81c\ud55c\uc801\uc774\uba70, \ub9ce\uc740 \ud658\uc790\uac00 \ub9d0\uae30 \uc2e0\uc7a5\uc9c8\ud658(ESRD)\uc73c\ub85c \uc9c4\ud589\ud558\uc5ec \uacb0\uad6d \ud22c\uc11d\uc774\ub098 \uc2e0\uc7a5\uc774\uc2dd\uc744 \ud544\uc694\ub85c \ud569\ub2c8\ub2e4. \uae09\uc131 \uc2e0\uc190\uc0c1(AKI) \ubcd1\ub825\uc774 \uc788\ub294 \ud658\uc790 \uc5ed\uc2dc \uc774\ud6c4 CKD \uc9c4\ud589 \uc704\ud5d8\uc774 \ub192\uc2b5\ub2c8\ub2e4. AKI\uc5d0\uc11c CKD\ub85c\uc758 \uc804\ud658\uc740 \ubd80\uc801\uc751\uc131 \uc870\uc9c1 \ud68c\ubcf5, \uc9c0\uc18d\uc801\uc778 \uc138\ub1e8\uad00 \uc138\ud3ec \uc2a4\ud2b8\ub808\uc2a4 \ubc0f \uc12c\uc720\ud654\uc131 \uc7ac\ud615\uc131\uacfc \uad00\ub828\ub429\ub2c8\ub2e4. \ub530\ub77c\uc11c \uacf5\ud1b5\uc801\uc778 \uc12c\uc720\ud654 \uad00\ub828 \uae30\uc804\uc744 \uc870\uc808\ud558\ub294 \uce58\ub8cc \uc811\uadfc\ubc95\uc740 CKD \uc9c4\ud589\uc744 \ub2a6\ucd94\ub294 \ub3d9\uc2dc\uc5d0, \ucd94\uac00 \uac80\uc99d\uc744 \ud1b5\ud574 \ub2e4\ub978 \uc12c\uc720\ud654\uc131 \uc9c8\ud658\uc5d0\ub3c4 \uc801\uc6a9 \uac00\ub2a5\uc131\uc774 \uc788\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n

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<\/span>\uc791\uc6a9 \uae30\uc804 \ubc0f \uc8fc\uc694 \ud2b9\uc9d5
\n<\/span><\/div>\n<\/div><\/div>\n\n

\uc120\ud0dd\uc801 NUAK1 \uc5b5\uc81c\ub97c \ud1b5\ud55c \uc12c\uc720\ud654 \uad00\ub828 YAP\/TAZ \uc2e0\ud638\uc804\ub2ec \uc870\uc808<\/h2>\n<\/div><\/div>\n\n
<\/span><\/a><\/div>\n\n

OCT-648\uc740 \uc12c\uc720\ud654 \uad00\ub828 YAP\/TAZ-NUAK1 \uc591\uc131 \ud53c\ub4dc\ubc31 \ub8e8\ud504\ub97c \ucc28\ub2e8\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uc120\ud0dd\uc801 NUAK1 \uc5b5\uc81c\uc81c \ud504\ub85c\uadf8\ub7a8\uc785\ub2c8\ub2e4. NUAK1 \uc5b5\uc81c\ub294 \uc138\ud3ec\uace8\uaca9 \uc7ac\ud615\uc131\uacfc YAP\/TAZ \uc804\uc0ac \ud65c\uc131\uc744 \uac10\uc18c\uc2dc\ucf1c \uc12c\uc720\ud654 \ucd09\uc9c4 \uc720\uc804\uc790 \ubc1c\ud604\uacfc \uc12c\uc720\uc544\uc138\ud3ec \ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub429\ub2c8\ub2e4. \uc774 \uae30\uc804\uc740 \uacf5\ud1b5\uc801\uc778 \uc12c\uc720\ud654 \uae30\ubc18 \uc9c8\ubcd1 \uacfc\uc815\uc5d0 \ub300\uc751\ud560 \uc218 \uc788\uc73c\uba70, \uc9c4\ud589\uc131 CKD\uc640 AKI \ud6c4 \ubd80\uc801\uc751\uc131 \ud68c\ubcf5\uc744 \uc8fc\uc694 \uac1c\ubc1c \uc601\uc5ed\uc73c\ub85c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.
\n\ube44\uc784\uc0c1 \uc2e0\uc7a5 \uc12c\uc720\ud654 \ubaa8\ub378\uc5d0\uc11c NUAK1 \uc5b5\uc81c\uc81c \ud6c4\ubcf4\uad70\uc740 \uc12c\uc720\ud654 \uba74\uc801, \uc12c\uc720\uc544\uc138\ud3ec \ud65c\uc131\ud654 \ubc0f \ucf5c\ub77c\uac90 \uce68\ucc29 \uac10\uc18c\uc640 \ud568\uaed8 \uc138\ud3ec \uc218\uc900\uc758 \ud45c\uc801 \uad00\uc5ec(target engagement) \ubc0f \u03b1-SMA \uc870\uc808\uc744 \ud3ec\ud568\ud55c \ud56d\uc12c\uc720\ud654 \ud65c\uc131\uc744 \ub098\ud0c0\ub0c8\uc2b5\ub2c8\ub2e4. \ub9cc\uc131 \uc2e0\uc7a5\uc9c8\ud658 \uc801\uc751\uc99d\uc5d0 \ud544\uc694\ud55c \uc548\uc804\uc5ed\uc744 \ud655\ubcf4\ud558\uae30 \uc704\ud55c \ucd94\uac00 \ud6c4\ubcf4\ubb3c\uc9c8 \ucd5c\uc801\ud654\uac00 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4.<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n

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<\/span>\uadfc\uac70 \uc790\ub8cc
\n<\/span><\/div>\n<\/div><\/div>\n\n

\uc8fc\uc694 \ub17c\ubb38 \ubc0f \ud559\uc220 \ubc1c\ud45c<\/h2>\n

OCT-648 NUAK1 \uc5b5\uc81c\uc81c \ud504\ub85c\uadf8\ub7a8 \uc5f0\uad6c<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n

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<\/span>
\n\ube44\uc784\uc0c1<\/div>\n
2026\/04<\/div>\n<\/div>\n

Development of Potent and Selective NUAK1 Inhibitors that Attenuate TGF-\u03b2\u2013Induced and UUO-Driven Renal Fibrosis via YAP Pathway Modulation
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ISN WCN 2026 \u00b7 Poster P522 \u00b7 Yoon J, et al.\n<\/p>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n

<\/div>\n<\/div>\n<\/div>\n\n
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<\/span>Paola Romagnani \uad50\uc218 \uc5f0\uad6c\uc2e4
\n<\/span><\/div>\n<\/div><\/div>\n\n

Paola Romagnani \uad50\uc218 \uc5f0\uad6c\uc2e4<\/h2>\n<\/div><\/div>\n\n

\uc774\ud0c8\ub9ac\uc544 \ud53c\ub80c\uccb4\ub300\ud559\uad50<\/p>\n<\/div><\/div>\n<\/div>\n\n

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\uc57d\uc5b4 \u2014 CKD: \ub9cc\uc131 \uc2e0\uc7a5\uc9c8\ud658 \u00b7 AKI: \uae09\uc131 \uc2e0\uc190\uc0c1 \u00b7 ESRD: \ub9d0\uae30 \uc2e0\uc7a5\uc9c8\ud658 \u00b7 IND: \uc784\uc0c1\uc2dc\ud5d8\uacc4\ud68d \u00b7 SoC: \ud45c\uc900 \uce58\ub8cc \u00b7 NUAK1: NUAK \uacc4\uc5f4 \ud0a4\ub098\uc544\uc81c 1 \u00b7 YAP: Yes-associated protein \u00b7 TAZ: PDZ \uacb0\ud569 \ubaa8\ud2f0\ud504\ub97c \uac00\uc9c4 \uc804\uc0ac \uacf5\ub3d9\ud65c\uc131\uc778\uc790 \u00b7 \u03b1-SMA: \uc54c\ud30c \ud3c9\ud65c\uadfc \uc561\ud2f4<\/p>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":406869,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"wpai_generated_summary":"","wpai_meta_description":"","footnotes":""},"class_list":["post-406919","page","type-page","status-publish","hentry"],"acf":[],"dsm_author":{"name":"Photong","avatar_url":"https:\/\/secure.gravatar.com\/avatar\/8f28831a4c55dba0b38a30b7d6e067203b6e781f27c8cc78bc3ca7d9a9e16ab8?s=96&d=mm&r=g","archive_link":"https:\/\/oscotec.com\/ko\/author\/photong\/","biodata":""},"dsm_categories":[],"dsm_attachment_categories":[],"dsm_featured_image":null,"dsm_comment_count":0,"_links":{"self":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406919","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/comments?post=406919"}],"version-history":[{"count":50,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406919\/revisions"}],"predecessor-version":[{"id":410333,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406919\/revisions\/410333"}],"up":[{"embeddable":true,"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/pages\/406869"}],"wp:attachment":[{"href":"https:\/\/oscotec.com\/ko\/wp-json\/wp\/v2\/media?parent=406919"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}